Article
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.
EMBO reports - 1 May 2015
Nitta Takeshi, Muro Ryunosuke, Shimizu Yukiko, Nitta Sachiko, Oda Hiroyo, Ohte Yuki, Goto Motohito, Yanobu-Takanashi Rieko, Narita Tomoya, Takayanagi Hiroshi, Yasuda Hisataka, Okamura Tadashi, Murata Shigeo, Suzuki Harumi
Abstract excerpt
The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe the significance of cortical TECs (cTECs) in T-cell development, using a newly established mouse model of cTEC deficiency. The deficiency of mature cTECs caused a massive loss of thymic cellularity and impaired the development of αβT cells and invariant...
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