Article
Mutation of Tec family kinases alters T helper cell differentiation.
Nature immunology - 1 Dec 2001
Schaeffer E M, Yap G S, Lewis C M, Czar M J, McVicar D W, Cheever A W, Sher A, Schwartzberg P L
Abstract excerpt
The Tec kinases Rlk and Itk are critical for full T cell receptor (TCR)-induced activation of phospholipase C-gamma and mitogen-activated protein kinase. We show here that the mutation of Rlk and Itk impaired activation of the transcription factors NFAT and AP-1 and production of both T helper type 1 (TH1) and TH2 cytokines. Consistent with these biochemical defects, Itk-/- mice did not generate effective TH2...
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