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Article

Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009

Gatzka Martina, Newton Ryan H, Walsh Craig M

Abstract excerpt

Negative regulation of TCR signaling is an important mechanism enforcing immunological self-tolerance to prevent inappropriate activation of T cells and thus the development of autoimmune diseases. The lymphoid-restricted serine/threonine kinase death-associated protein-related apoptotic kinase-2 (DRAK2) raises the TCR activation threshold by targeting TCR-induced calcium mobilization in thymocytes and peripheral...

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Source

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Identifiers

PMID: 19542440
DOI: 10.4049/jimmunol.0803530
PMCID: PMC2724075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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