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Article

Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009

Gatzka Martina, Newton Ryan H, Walsh Craig M

Abstract excerpt

Negative regulation of TCR signaling is an important mechanism enforcing immunological self-tolerance to prevent inappropriate activation of T cells and thus the development of autoimmune diseases. The lymphoid-restricted serine/threonine kinase death-associated protein-related apoptotic kinase-2 (DRAK2) raises the TCR activation threshold by targeting TCR-induced calcium mobilization in thymocytes and peripheral...

Topics

Animals
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Differentiation
Clone Cells
Down-Regulation
Encephalomyelitis, Autoimmune, Experimental
Genetic Predisposition to Disease
Immunophenotyping
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Organ Specificity

Protein Serine-Threonine Kinases

Receptors, Antigen, T-Cell

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19542440
DOI: 10.4049/jimmunol.0803530
PMCID: PMC2724075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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