Article
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
eLife - 1 Jan 2014
Sojka Dorothy K, Plougastel-Douglas Beatrice, Yang Liping, Pak-Wittel Melissa A, Artyomov Maxim N, Ivanova Yulia, Zhong Chao, Chase Julie M, Rothman Paul B, Yu Jenny, Riley Joan K, Zhu Jinfang, Tian Zhigang, Yokoyama Wayne M
Abstract excerpt
Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells in the spleen. Recently, we described two populations of liver NK cells, tissue-resident NK (trNK) cells and those resembling splenic cNK cells. However, their...
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