Article
Association of a mutation in TRPV3 with defective hair growth in rodents.
The Journal of investigative dermatology - 1 Dec 2006
Asakawa Makoto, Yoshioka Takeshi, Matsutani Takaji, Hikita Ichiro, Suzuki Minoru, Oshima Itsuki, Tsukahara Kiyoshi, Arimura Akinori, Horikawa Tatsuya, Hirasawa Tsutomu, Sakata Tsuneaki
Abstract excerpt
DS-Nh mice and WBN/Kob-Ht rats are spontaneous hairless mutant rodent strains. These animals develop spontaneous dermatitis under normal conditions. The non-hair Nh and Ht phenotypes are inherited in an autosomal dominant fashion, and the Nh mutation possesses a high potency for penetration. We previously reported that genes involved in dermatitis and hairlessness did not segregate from each other. Here, we...
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