Article
Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.
The Journal of investigative dermatology - 1 Mar 2009
Yoshioka Takeshi, Imura Kinichi, Asakawa Makoto, Suzuki Minoru, Oshima Itsuki, Hirasawa Tsutomu, Sakata Tsuneaki, Horikawa Tatsuya, Arimura Akinori
Abstract excerpt
We reported that the Gly573Ser substitution in transient receptor potential vanilloid 3 (TRPV3) led to increased ion channel activity in keratinocytes and caused spontaneous hairlessness in DS-Nh mice. DS-Nh mice also develop allergic and pruritic dermatitis. As the hairless and dermatitis phenotypes were both inherited in an autosomal dominant fashion and could not be segregated from each other, we speculated...
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