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Article

The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes.

The Journal of biological chemistry - 13 Jun 2008

Nanashima Naoki, Akita Miki, Yamada Toshiyuki, Shimizu Takeshi, Nakano Hajime, Fan Yang, Tsuchida Shigeki

Abstract excerpt

Most models of hereditary hypotrichosis are due to alterations in growth factors and transcription factors, and the examples of causative mutations in hair keratin genes are limited. The Hirosaki hairless rat (HHR) is a mutant strain spontaneously derived from Sprague-Dawley rats (SDRs). In this study, the locus of the responsible gene was examined by linkage analysis and mapped on chromosome 7q36. Because many...

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PMID: 18420582
DOI: 10.1074/jbc.M802539200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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