Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine.

Abstract excerpt

The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders. Gain-of-function mutations of TRPV3 cause hair growth disorders in mice and Olmsted syndrome in humans. Nevertheless, whether and how TRPV3 could be therapeutically targeted remains to be elucidated. We here...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anesthetics, Local
• Share to Behavior, Animal