Article
Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
2020-09-22
Abstract excerpt
The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders. Gain-of-function mutations of TRPV3 cause hair growth disorders in mice and Olmsted Syndrome in human. Nevertheless, whether and how TRPV3 could be therapeutically targeted remains to be elucidated. We here repo...
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Identifiers and source
- Literature Corpus work
- f6c35098-b2ed-5657-8c08-83b9d814f53e
- DOI
- 10.1101/2020.09.21.306316