Article
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active.
Cell calcium - 1 Apr 2008
Xiao Rui, Tian Jinbin, Tang Jisen, Zhu Michael X
Abstract excerpt
TRPV3 is a non-selective cation channel activated by warm to hot temperatures. In rodents, TRPV3 is highly expressed in basal keratinocytes of skin and oral/nasal epithelia. TRPV3 knockout mice showed impaired responses to innocuous and noxious heat but otherwise normal appearance and reactions to many sensory modalities. However, point mutations of TRPV3 at Gly573 to Ser and Cys have recently been linked to...
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