Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.

The Journal of physiology - 1 Jul 2016

Voisin Tiphaine, Bourinet Emmanuel, Lory Philippe

Abstract excerpt

KEY POINTS: In this study, we describe a new knock-in (KI) mouse model that allows the study of the H191-dependent regulation of T-type Cav3.2 channels. Sensitivity to zinc, nickel and ascorbate of native Cav3.2 channels is significantly impeded in the dorsal root ganglion (DRG) neurons of this KI mouse. Importantly, we describe that this H191-dependent regulation has discrete but significant effects on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Ascorbic Acid
Share to Calcium Channels, T-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganglia, Spinal

Share to Histidine

Share to Nickel

Share to Oxidation-Reduction

Source

Open in PubMed Open full text

Identifiers

PMID: 26931411
DOI: 10.1113/JP271925
PMCID: PMC4929317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.PMID 26931411Read ↗

Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels.Semantic proximity Read ↗

Ins and outs of T-channel structure function.Semantic proximity Read ↗

Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG NeuronsSemantic proximity Read ↗

A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels.Semantic proximity Read ↗

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensationSemantic proximity Read ↗

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.Semantic proximity Read ↗

Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.Semantic proximity Read ↗

Life and death of sensory hair cells expressing constitutively active TRPML3.Semantic proximity Read ↗

Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neuronsSemantic proximity Read ↗

Intracellular zinc protects Kv7 K+ channels from Ca2+/calmodulin-mediated inhibition.Semantic proximity Read ↗

A startling role for synaptic zinc.Semantic proximity Read ↗

A T-type calcium channel required for normal function of a mammalian mechanoreceptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.