Article
The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.
Cancer research - 15 Jan 2021
Milanovic Maja, Sprinzen Lisa, Menolfi Demis, Lee Ji-Hoon, Yamamoto Kenta, Li Yang, Lee Brian J, Xu Jun, Estes Verna M, Wang Dong, Mckinnon Peter J, Paull Tanya T, Zha Shan
Abstract excerpt
ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead (KD) ATM protein solely accelerates lymphomagenesis beyond ATM loss. To understand how PRD suppresses lymphomagenesis, we introduced the cancer-associated PRD mutation R3008H...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.