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Article

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.

The Journal of cell biology - 28 Dec 2009

So Sairei, Davis Anthony J, Chen David J

Abstract excerpt

Ataxia telangiectasia mutated (ATM) plays a critical role in the cellular response to DNA damage. In response to DNA double-strand breaks (DSBs), ATM is autophosphorylated at serine 1981. Although this autophosphorylation is widely considered a sign of ATM activation, it is still not clear if autophosphorylation is required for ATM functions including localization to DSBs and activation of ATM kinase activity. In...

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Share to Acid Anhydride Hydrolases
Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20026654
DOI: 10.1083/jcb.200906064
PMCID: PMC2806275

Genes

ATM
MDC1
MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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