Article

Epigenomic analysis of hepatocellular carcinoma reveals aberrant <i>cis</i> -regulatory changes and dysregulated retrotransposons with prognostic potentials

2024-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Hepatocellular carcinoma (HCC) exhibits widespread epigenetic alterations, yet their impact on cis -regulatory elements (CREs) and retrotransposons remains poorly understood. Here, we present an integrated epigenomic and transcriptomic analysis of HCC tumors and matched tumor-adjacent normal tissues. We identified extensive DNA hypomethylation coupled with changes in histone modifications at pa...

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Literature Corpus work: 052d6698-37c6-512d-ae40-7b42511cb78b
DOI: 10.1101/2024.09.16.613254

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Epigenomic analysis of hepatocellular carcinoma reveals aberrant <i>cis</i> -regulatory changes and dysregulated retrotransposons with prognostic potentialsDOI 10.1101/2024.09.16.613254Read

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