Article

Promoter DNA Methylation Epigenetically Regulates the Tumor-Suppressor Function of the miR-379/656 (C14MC) Cluster in Hepatocellular Carcinoma

2025-12-04

Abstract excerpt

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Several microRNAs (miRNAs) play key roles in HCC development and progression. The role of epigenetic processes like DNA methylation in the regulation of miRNAs is critical to HCC pathogenesis. In this study, we show that the miR-379/656 cluster (C14MC) acts as a tumor suppressor cluster and is epigenetically regulated by DNA methylation...

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Literature Corpus work: 08f38e89-3da8-5fd4-8e72-8c884ca83585
DOI: 10.64898/2025.12.02.691781

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