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Aberrant promoter methylation of <i>PPP1R3C</i> and <i>EFHD1</i> in plasma of colorectal cancer patients

24 May 2014

Abstract excerpt

Aberrant DNA methylation is a common epigenetic alteration involved in colorectal cancer (CRC). In our previous study, we performed methylated DNA immunoprecipitation-on-chip analysis combined with gene re-expression analysis by 5-aza-2'-deoxycytidine treatment, to identify methylation genes in CRC genome widely. Among these genes, 12 genes showed aberrant hypermethylation frequently in >75% of 149 CRC samples...

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PMID: 24861485
DOI: 10.1002/cam4.273

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