Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CpG island methylator phenotype association with elevated serum alpha-fetoprotein level in hepatocellular carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2007

Zhang Changsong, Li Zhengyou, Cheng Yue, Jia Fengqi, Li Rong, Wu Mengchao, Li Ke, Wei Lixin

Abstract excerpt

PURPOSE: CpG island methylator phenotype (CIMP) involves hypermethylation targeted toward the promoters of multiple genes. To gain insight into the role of epigenetic aberration of tumor-related genes in hepatocarcinogenesis, we determined a hypermethylation profile in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN: We examined the promoter methylation status of nine genes in 50 HCCs, 50 paired nontumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Fetoproteins
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to DNA Primers

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17289889
DOI: 10.1158/1078-0432.CCR-06-2268

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CpG island methylator phenotype association with elevated serum alpha-fetoprotein level in hepatocellular carcinoma.PMID 17289889Read ↗

CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma.Semantic proximity Read ↗

Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma.Semantic proximity Read ↗

CpG island methylator phenotype in plasma is associated with hepatocellular carcinoma prognosis.Semantic proximity Read ↗

Prognostic value of CpG island methylator phenotype among hepatocellular carcinoma patients: A systematic review and meta-analysis.Semantic proximity Read ↗

DNA methylation markers and serum α-fetoprotein level are prognostic factors in hepatocellular carcinomaSemantic proximity Read ↗

CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma.Semantic proximity Read ↗

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkersSemantic proximity Read ↗

Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.Semantic proximity Read ↗

Clinical implications of DNA methylation in hepatocellular carcinoma.Semantic proximity Read ↗

The role of CpG island methylator phenotype in the clinical course of hepatocellular carcinoma.Semantic proximity Read ↗

Methylation profile of the promoter CpG islands of 14 “drug-resistance” genes in hepatocellular carcinomaSemantic proximity Read ↗

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.