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Article

Role of proto-oncogene activation in carcinogenesis.

1 Nov 1992

Abstract excerpt

The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been observed in the development of human colon and lung tumors. Point mutations in key codons can...

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Identifiers

PMID: 1486840
DOI: 10.1289/ehp.929813

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Source receipt: pubmed, retrieved 7 Sept 2026.

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