Article
The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner.
The Journal of general virology - 1 Aug 2006
Casartelli Nicoletta, Giolo Giorgia, Neri Francesca, Haller Claudia, Potestà Marina, Rossi Paolo, Fackler Oliver T, Doria Margherita
Abstract excerpt
The Nef protein is a crucial pathogenicity factor of human immunodeficiency virus type 1 (HIV-1) that contains a proline-rich motif consisting of four conserved prolines: Pro69 (P69), P72, P75 and P78. P72 and P75 were shown to bind Src homology domains 3 (SH3) and have been implicated in many biological functions of Nef, including downmodulation of cell-surface major histocompatibility complex class I (MHC-I)....
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