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Article

HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2005

Drakesmith Hal, Chen Nan, Ledermann Hannah, Screaton Gavin, Townsend Alain, Xu Xiao-Ning

Abstract excerpt

The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis. In model cell lines, Nef reroutes HFE to a...

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Source

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Identifiers

PMID: 16043695
DOI: 10.1073/pnas.0504823102
PMCID: PMC1180511

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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