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A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

2021-03-31

Abstract excerpt

<h4>SUMMARY</h4> The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-dependent trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting of Env. Despite extensive characterization, the role of these functions in viral infection and pathogenesis is unclear. An SIV molecular clone (SIVmac239) in which the Tyr-based signal is inactivated by dele...

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Literature Corpus work
6361bb85-53b7-51eb-a4bf-9baf45f4f4a7
DOI
10.1101/2021.03.31.437834
Open publication

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A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infectionDOI 10.1101/2021.03.31.437834
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