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Article

The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Chaudhry Ashutosh, Das Suman Ranjan, Hussain Amjad, Mayor Satyajit, George Anna, Bal Vineeta, Jameel Shahid, Rath Satyajit

Abstract excerpt

The Nef protein of HIV-1 is essential for its pathogenicity and is known to down-regulate MHC expression on infected cell surfaces. We now show that Nef also redistributes the costimulatory molecules CD80 and CD86 away from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells. Furthermore, HIV-1-infected U937 cells and human blood-derived macrophages show a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16177101
DOI: 10.4049/jimmunol.175.7.4566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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