Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.

doi:10.1038/ng.305

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Article

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.

Nature genetics - 1 Feb 2009

Carrasquillo Minerva M, Zou Fanggeng, Pankratz V Shane, Wilcox Samantha L, Ma Li, Walker Louise P, Younkin Samuel G, Younkin Curtis S, Younkin Linda H, Bisceglio Gina D, Ertekin-Taner Nilufer, Crook Julia E, Dickson Dennis W, Petersen Ronald C, Graff-Radford Neill R, Younkin Steven G

Abstract excerpt

By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504 SNPs, three series, 844 cases and 1,255 controls) and evaluating the 25 SNPs with the most significant allelic association in four additional series (1,547 cases and 1,209 controls), we identified a SNP (rs5984894) on Xq21.3 in PCDH11X that is strongly associated with LOAD in individuals of European descent from the...

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PMID: 19136949
DOI: 10.1038/ng.305
PMCID: PMC2873177

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