Article
Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jul 2017
Hu Yang, Cheng Liang, Zhang Ying, Bai Weiyang, Zhou Wenyang, Wang Tao, Han Zhifa, Zong Jian, Jin Shuilin, Zhang Jun, Jiang Qinghua, Liu Guiyou
Abstract excerpt
In 2006, a candidate gene study reported death-associated protein kinase 1 (DAPK1) rs4878104 variant to be significantly associated with Alzheimer's disease (AD) risk. However, the following studies showed inconsistent association results. Here, we conducted an updated analysis to investigate the potential association between rs4878104 and AD using a total of 60,751 samples (20,161 AD cases and 40,590 controls)....
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