Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2014

Kyriakou Theodosios, Seedorf Udo, Goel Anuj, Hopewell Jemma C, Clarke Robert, Watkins Hugh, Farrall Martin

Abstract excerpt

OBJECTIVE: Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common null allele of LPA with lipoprotein(a) levels and CAD risk in a large case-control cohort. We have also examined how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoprotein(a)
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to Electrophoresis, Agar Gel

Share to High-Throughput Screening Assays

Share to Kringles

Share to Protein Isoforms

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 24925971
DOI: 10.1161/ATVBAHA.114.303462

Genes

CAD
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk.PMID 24925971Read ↗

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis.Semantic proximity Read ↗

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.Semantic proximity Read ↗

Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk.Semantic proximity Read ↗

Lipoprotein(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a).Semantic proximity Read ↗

Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.Semantic proximity Read ↗

Genetic variants associated with Lp(a) lipoprotein level and coronary disease.Semantic proximity Read ↗

Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases.Semantic proximity Read ↗

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.Semantic proximity Read ↗

Lipoprotein(a): An independent, genetic, and causal factor for cardiovascular disease and acute myocardial infarctionSemantic proximity Read ↗

Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic GroupsSemantic proximity Read ↗

Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.Semantic proximity Read ↗

Lipoprotein(a)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.