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Article

The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.

American journal of human genetics - 1 Aug 1997

Mooser V, Scheer D, Marcovina S M, Wang J, Guerra R, Cohen J, Hobbs H H

Abstract excerpt

The distributions of plasma lipoprotein(a), or Lp(a), levels differ significantly among ethnic groups. Individuals of African descent have a two- to threefold higher mean plasma level of Lp(a) than either Caucasians or Orientals. In Caucasians, variation in the plasma Lp(a) levels has been shown to be largely determined by sequence differences at the apo(a) locus, but little is known about either the genetic...

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Identifiers

PMID: 9311746
DOI: 10.1086/514851
PMCID: PMC1715889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.PMID 9311746Read ↗

Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.Semantic proximity Read ↗

Significant associations between lipoprotein(a) and corrected apolipoprotein B-100 levels in African-Americans.Semantic proximity Read ↗

The apolipoprotein(a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians.Semantic proximity Read ↗

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.Semantic proximity Read ↗

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.Semantic proximity Read ↗

Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus.Semantic proximity Read ↗

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.Semantic proximity Read ↗

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ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study.Semantic proximity Read ↗

Significant impact of the +93 C/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: confounding effect of linkage disequilibrium.Semantic proximity Read ↗

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