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Article

Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk.

Journal of the American Heart Association - 18 Jun 2024

Volgman Annabelle Santos, Koschinsky Marlys L, Mehta Anurag, Rosenson Robert S

Abstract excerpt

Elevated lipoprotein(a) is a genetically transmitted codominant trait that is an independent risk driver for cardiovascular disease. Lipoprotein(a) concentration is heavily influenced by genetic factors, including LPA kringle IV-2 domain size, single-nucleotide polymorphisms, and interleukin-1 genotypes. Apolipoprotein(a) is encoded by the LPA gene and contains 10 subtypes with a variable number of copies of...

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Source

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Identifiers

PMID: 38879448
DOI: 10.1161/JAHA.123.033654
PMCID: PMC11255763

Genes

LPA
APOE
APOH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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