Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk.

doi:10.1161/JAHA.123.033654

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Article

Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk.

Journal of the American Heart Association - 18 Jun 2024

Volgman Annabelle Santos, Koschinsky Marlys L, Mehta Anurag, Rosenson Robert S

Abstract excerpt

Elevated lipoprotein(a) is a genetically transmitted codominant trait that is an independent risk driver for cardiovascular disease. Lipoprotein(a) concentration is heavily influenced by genetic factors, including LPA kringle IV-2 domain size, single-nucleotide polymorphisms, and interleukin-1 ge...

Topics

Humans
Lipoprotein(a)
Cardiovascular Diseases
Heart Disease Risk Factors
Genetic Predisposition to Disease
Risk Assessment
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 38879448
DOI: 10.1161/JAHA.123.033654
PMCID: PMC11255763

Genes

LPA
APOE
APOH

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38879448-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.