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Article

Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases.

Progress in lipid research - 1 Jun 2026

Antipenko Ivan, Stepanova Anna, Shkurnikov Maxim, Jeiran Kianoush, Baranova Ancha, Tonevitsky Alexander

Abstract excerpt

Lipoprotein (a) [Lp(a)] is a highly heterogeneous lipoprotein particle promoting panvascular disease. Structurally, it consists of an LDL-like core covalently bound to apolipoprotein (a) [apo(a)]. Molecular determinants linking various genetic variants of apo(a) constituent of Lp(a) to vascular pathology remain incompletely defined. We have built a model allowing dissection which variations in LPA gene are...

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Source

Identifiers

PMID: 41453575
DOI: 10.1016/j.plipres.2025.101375

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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