Article
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.
Molecular genetics and metabolism - 1 Jan 2000
Tsuchiya Takafumi, Schwarz Peter E H, Bosque-Plata Laura Del, Geoffrey Hayes M, Dina Christian, Froguel Philippe, Wayne Towers G, Fischer Sabine, Temelkova-Kurktschiev Theodora, Rietzsch Hannes, Graessler Juergen, Vcelák Josef, Palyzová Daniela, Selisko Thomas, Bendlová Bela, Schulze Jan, Julius Ulrich, Hanefeld Markolf, Weedon Michael N, Evans Julie C, Frayling Timothy M, Hattersley Andrew T, Orho-Melander Marju, Groop Leif, Malecki Maciej T, Hansen Torben, Pedersen Oluf, Fingerlin Tasha E, Boehnke Michael, Hanis Craig L, Cox Nancy J, Bell Graeme I
Abstract excerpt
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence...
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