Article
Type 2 diabetes candidate gene CAPN10: first, but not last.
Current hypertension reports - 1 Feb 2008
Ridderstråle Martin, Nilsson Emma
Abstract excerpt
CAPN10, which encodes the cysteine protease calpain 10, was the first type 2 diabetes mellitus (T2DM) susceptibility gene identified through a genome-wide scan followed by positional cloning. A haplotype combination comprising three intronic CAPN10 single-nucleotide polymorphisms (UCSNP-43, -19, and -63) was associated with increased risk of T2DM in the population in which linkage was first found. Follow-up...
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