Article
Association of calpain-10 polymorphisms with type 2 diabetes in the Tunisian population.
Diabetes & metabolism - 1 Jun 2008
Kifagi C, Makni K, Mnif F, Boudawara M, Hamza N, Rekik N, Abid M, Rebaï A, Granier C, Jarraya F, Ayadi H
Abstract excerpt
BACKGROUND: Genome-wide analyses of the genetic predisposition to type 2 diabetes mellitus (T2DM) in different isolates and populations have identified regions of interest called non insulin-dependent diabetes mellitus (NIDDM) 1, 2, 3 and 4. At the NIDDM1 locus (2q37.3), calpain-10 (CAPN10) encodes for a ubiquitously expressed protease implicated in the two fundamental pathophysiological aspects of T2DM. This is...
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