Article
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
American journal of human genetics - 1 Sept 2001
Evans J C, Frayling T M, Cassell P G, Saker P J, Hitman G A, Walker M, Levy J C, O'Rahilly S, Rao P V, Bennett A J, Jones E C, Menzel S, Prestwich P, Simecek N, Wishart M, Dhillon R, Fletcher C, Millward A, Demaine A, Wilkin T, Horikawa Y, Cox N J, Bell G I, Ellard S, McCarthy M I, Hattersley A T
Abstract excerpt
Variation in CAPN10, the gene encoding the ubiquitously expressed cysteine protease calpain-10, has been associated with type 2 diabetes in Mexican Americans and in two northern-European populations, from Finland and Germany. We have studied CAPN10 in white subjects of British/Irish ancestry, using both family-based and case-control studies. In 743 sib pairs, there was no evidence of linkage at the CAPN10 locus,...
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