Association of Calpain-10 gene polymorphisms with Type 2 diabetes mellitus: a case-control study from a tertiary care hospital in Pakistan.

doi:10.1186/s12920-025-02152-1

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Article

Association of Calpain-10 gene polymorphisms with Type 2 diabetes mellitus: a case-control study from a tertiary care hospital in Pakistan.

BMC medical genomics - 19 May 2025

Farooqi Humaira, Choudhry Nakhshab, Saddique Muhammad Nabeel, Qamar Samina, Dar Rehma, Kazmi Salman, Gondal Aamir Jamal, Yasmin Nighat, Javaid Hammad, Nahla Ursula Abu

Abstract excerpt

INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a major public health challenge, with rising prevalence in low- and middle-income countries such as Pakistan. Genetic susceptibility plays a critical role in its pathogenesis. Calpain-10 (CAPN-10), a gene implicated in insulin secretion and glucose homeostasis, has been studied for its potential involvement in T2DM. This study aimed to evaluate the association of...

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Topics

Humans
Diabetes Mellitus, Type 2
Calpain
Male
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Case-Control Studies

Pakistan

Aged

Adult

Genetic Predisposition to Disease

Tertiary Care Centers

Aged, 80 and over

Genetic Association Studies

Gene Frequency

Source

Open in PubMed Open full text

Identifiers

PMID: 40389979
DOI: 10.1186/s12920-025-02152-1
PMCID: PMC12087112

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