Article
Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study.
BMC medical genetics - 15 May 2010
Ezzidi Intissar, Turki Amira, Messaoudi Safia, Chaieb Molka, Kacem Maha, Al-Khateeb Ghada M, Mahjoub Touhami, Almawi Wassim Y, Mtiraoui Nabil
Abstract excerpt
BACKGROUND: Genetic variations in the calpain-10 gene (CAPN10), in particular the at-risk diplotype (112/121), were previously implicated with increased risk of type 2 diabetes (T2D). METHODS: We examined the association of CAPN10 UCSNP-43 (rs3792267), UCSNP-19 (rs3842570), and UCSNP-63 (rs5030952) SNPs with T2D in 917 Tunisian T2D patients and 748 non-diabetic controls. CAPN10 genotyping was done by PCR-RFLP....
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