Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.

doi:10.3233/JAD-2012-120358

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Article

Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Lanni Cristina, Garbin Giulia, Lisa Antonella, Biundo Fabrizio, Ranzenigo Alberto, Sinforiani Elena, Cuzzoni Giovanni, Govoni Stefano, Ranzani Guglielmina Nadia, Racchi Marco

Abstract excerpt

COMT (Catechol-O methyltransferase) gene is one of the key players in synaptic plasticity and in learning and memory mechanisms. A single nucleotide polymorphism (rs4680; G to A) in the COMT coding region causes Val158Met aminoacid substitution in the corresponding protein, with Val allele exhibiting a 3- to 4-fold increase in enzyme activity compared to Met. With the purpose of examining the influence of COMT as...

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Identifiers

PMID: 22890094
DOI: 10.3233/JAD-2012-120358

Genes

COMT
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.PMID 22890094Read ↗

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