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Article

Catechol-o-methyltransferase and Alzheimer's disease: a review of biological and genetic findings.

CNS & neurological disorders drug targets - 1 May 2012

Serretti Alessandro, Olgiati Paolo

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia worldwide and is associated with a marked individual, familial and social burden. Catechol-O-mehyltransferase (COMT) is surfacing with a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. COMT gene regulates dopamine levels in the prefrontal cortex which are involved in working memory and...

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Source

Identifiers

PMID: 22483294
DOI: 10.2174/187152712800672472

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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