Article
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.
Nature - 16 Sept 1999
Lin C R, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisúa-Belmonte J C, Rosenfeld M G
Abstract excerpt
Pitx1 and Pitx2 are highly homologous, bicoid-related transcription factors. Pitx2 was initially identified as the gene responsible for the human Rieger syndrome, an autosomal dominant condition that causes developmental abnormalities. Pitx2 is asymmetrically expressed in the left lateral-plate mesoderm, and mutant mice with laterality defects show altered patterns of Pitx2 expression that correlate with changes...
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