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Article

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.

Development (Cambridge, England) - 1 Apr 2006

Nowotschin Sonja, Liao Jun, Gage Philip J, Epstein Jonathan A, Campione Marina, Morrow Bernice E

Abstract excerpt

Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1, lies within the nested 1.5 Mb interval and is a strong candidate for its etiology. Inactivation of Tbx1 in the mouse results in...

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Source

Identifiers

PMID: 16556915
DOI: 10.1242/dev.02309

Genes

TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.PMID 16556915Read ↗

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The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioningSemantic proximity Read ↗

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Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium.Semantic proximity Read ↗

Multiple Roles of Pitx2 in Cardiac Development and DiseaseSemantic proximity Read ↗

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