Article
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.
Development (Cambridge, England) - 1 Apr 2006
Nowotschin Sonja, Liao Jun, Gage Philip J, Epstein Jonathan A, Campione Marina, Morrow Bernice E
Abstract excerpt
Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1, lies within...
Topics
- Animals
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental
- Heart
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Mutation
- Myocardium
- Nuclear Proteins
- T-Box Domain Proteins
- Transcription Factors
- Homeobox Protein PITX2