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Article

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

Blood - 1 Dec 2008

McDaniel Andrew S, Allen Jayme D, Park Su-Jung, Jaffer Zahara M, Michels Elizabeth G, Burgin Sarah J, Chen Shi, Bessler Waylan K, Hofmann Clemens, Ingram David A, Chernoff Jonathan, Clapp D Wade

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common genetic disorder caused by mutations in the NF1 locus, which encodes neurofibromin, a negative regulator of Ras. Patients with NF1 develop numerous neurofibromas, which contain many inflammatory mast cells that contribute to tumor formation. Subsequent to c-Kit stimulation, signaling from Ras to Rac1/2 to the MAPK pathway appears to be responsible for multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18768391
DOI: 10.1182/blood-2008-04-155085
PMCID: PMC2597131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.PMID 18768391Read ↗

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