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Emerging therapeutic targets for neurofibromatosis type 1

18 Apr 2018

Abstract excerpt

INTRODUCTION: Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited tumor predisposition syndrome with an incidence of one in 3000-4000 individuals with no currently effective therapies. The NF1 gene encodes neurofibromin, which functions as a negative regulator of RAS. NF1 is a chronic multisystem disorder affecting many different tissues. Due to cell-specific complexities of RAS signaling,...

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PMID: 29667529
DOI: 10.1080/14728222.2018.1465931

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