Article
Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.
Neurosurgical focus - 1 Jan 2010
Gottfried Oren N, Viskochil David H, Couldwell William T
Abstract excerpt
Neurofibromatosis Type 1 (NF1) is a common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors, and less frequently by malignant peripheral nerve sheath tumors (MPNSTs) and optic nerve gliomas. Significant advances have been made in elucidating the cellular, genetic, and molecular biology involved in tumor formation in NF1. Neurofibromatosis Type 1 is caused by germline...
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