Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

Nature chemical biology - 1 Aug 2006

Sanna M Germana, Wang Sheng-Kai, Gonzalez-Cabrera Pedro J, Don Anthony, Marsolais David, Matheu Melanie P, Wei Sindy H, Parker Ian, Jo Euijung, Cheng Wei-Chieh, Cahalan Michael D, Wong Chi-Huey, Rosen Hugh

Abstract excerpt

Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through genetic manipulations and (ii) to investigate their potential for therapeutic modulation. Vascular (but not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anilides
Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Lymph Nodes

Share to Lysophospholipids

Share to Organophosphonates

Share to Sphingosine

Share to Stereoisomerism

Source

Identifiers

PMID: 16829954
DOI: 10.1038/nchembio804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.PMID 16829954Read ↗

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammationSemantic proximity Read ↗

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.Semantic proximity Read ↗

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory ActivitiesSemantic proximity Read ↗

Modulating Sphingosine-1-Phosphate receptors to improve chemotherapy delivery to Ewing sarcomaSemantic proximity Read ↗

Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.Semantic proximity Read ↗

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.Semantic proximity Read ↗

S1pr1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lungSemantic proximity Read ↗

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesisSemantic proximity Read ↗

Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration.Semantic proximity Read ↗

GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.Semantic proximity Read ↗

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ FormationSemantic proximity Read ↗

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.