Article

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ Formation

2024-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Lymphatic vessels function throughout the body to drain interstitial fluids. Efficient lymph flow is ensured by lymphatic valves (LVs). However, the mechanisms that regulate LV development are incompletely understood. Here, we show that the deletion of the GPCR sphingosine 1-phosphate receptor-1 (S1PR1) from lymphatic endothelial cells (LECs) results in fewer LVs. Interestingly, LVs that remaine...

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Literature Corpus work: 46ec4101-0304-5b45-84ca-9be4b56b9a3a
DOI: 10.1101/2024.09.30.615915

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