Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.

doi:10.1016/j.febslet.2007.06.064

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Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.

FEBS letters - 24 Jul 2007

Ferry Gilles, Giganti Adeline, Cogé Francis, Bertaux Fabien, Thiam Kader, Boutin Jean A

Abstract excerpt

Autotaxin is a member of the phosphodiesterase family of enzymes, (NPP2). It is an important secreted protein found in conditioned medium from adipocytes. It also has a putative role in the metastatic process. Based on these observation, further validation of this potential target was necessary,...

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Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.

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