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Article

Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.

BMC biology - 7 Jul 2006

Anderson Michael G, Libby Richard T, Mao Mao, Cosma Ioan M, Wilson Larry A, Smith Richard S, John Simon W M

Abstract excerpt

BACKGROUND: DBA/2J (D2) mice develop an age-related form of glaucoma. Their eyes progressively develop iris pigment dispersion and iris atrophy followed by increased intraocular pressure (IOP) and glaucomatous optic nerve damage. Mutant alleles of the Gpnmb and Tyrp1 genes are necessary for the iris disease, but it is unknown whether alleles of other D2 gene(s) are necessary for the distinct later stages of...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16827931
DOI: 10.1186/1741-7007-4-20
PMCID: PMC1543659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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