Article
Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice.
Disease models & mechanisms - 19 Feb 2021
Tolman Nicholas G, Balasubramanian Revathi, Macalinao Danilo G, Kearney Alison L, MacNicoll Katharine H, Montgomery Christa L, de Vries Wilhelmine N, Jackson Ian J, Cross Sally H, Kizhatil Krishnakumar, Nair K Saidas, John Simon W M
Abstract excerpt
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better understand the mechanisms underlying LMX1B-related phenotypes and individual differences, we backcrossed the Lmx1bV265D (also known as Lmx1bIcst ) allele onto the...
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