Article
The severity of retinal degeneration in Rp1h gene-targeted mice is dependent on genetic background.
Investigative ophthalmology & visual science - 1 Apr 2009
Liu Qin, Saveliev Alexei, Pierce Eric A
Abstract excerpt
PURPOSE: The severity of disease in patients with retinitis pigmentosa (RP) can vary significantly, even among patients with the same primary mutations. It is hypothesized that modifier genes play important roles in determining the severity of RP, including the retinitis pigmentosa 1 (RP1) form of disease. To investigate the basis of variation in disease expression for RP1 disease, the authors generated congenic...
Topics
- Animals
- Crosses, Genetic
- Electroretinography
- Gene Targeting
- Genetic Predisposition to Disease
- Image Processing, Computer-Assisted
- Mice
- Mice, Congenic
- Mice, Inbred A
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Microscopy, Fluorescence
- Microtubule-Associated Proteins
- Phenotype