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Article

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.

BMC genetics - 3 Jul 2007

Howell Gareth R, Libby Richard T, Marchant Jeffrey K, Wilson Lawriston A, Cosma Ioan M, Smith Richard S, Anderson Michael G, John Simon W M

Abstract excerpt

BACKGROUND: The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the...

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Identifiers

PMID: 17608931
DOI: 10.1186/1471-2156-8-45
PMCID: PMC1937007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17608931-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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