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Article

Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.

Nature genetics - 1 Jan 2002

Anderson Michael G, Smith Richard S, Hawes Norman L, Zabaleta Adriana, Chang Bo, Wiggs Janey L, John Simon W M

Abstract excerpt

Pigmentary glaucoma is a significant cause of human blindness. Abnormally liberated iris pigment and cell debris enter the ocular drainage structures, leading to increased intraocular pressure (IOP) and glaucoma. DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (IPD) and iris stromal atrophy (ISA). Using high-resolution mapping techniques, sequencing and functional genetic...

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Source

Identifiers

PMID: 11743578
DOI: 10.1038/ng794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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