The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.

doi:10.1038/sj.onc.1202214

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Article

The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.

Oncogene - 10 Dec 1998

Denissenko M F, Koudriakova T B, Smith L, O'Connor T R, Riggs A D, Pfeifer G P

Abstract excerpt

Sequence-dependent formation and lack of repair of polycyclic aromatic hydrocarbon-induced DNA adducts correlates well with the positions of p53 mutational hotspots in smoking-related lung cancers (Denissenko et al, 1996, 1998). The mycotoxin aflatoxin B1 (AFB1) is considered to be a major causat...

Topics

Aflatoxin B1
Animals
Binding Sites
Carcinoma, Hepatocellular
Codon
DNA Adducts
Genes, p53
Humans
Mutagens
Mutation
Rats
Tumor Cells, Cultured

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